Strum J M
Cell Tissue Res. 1978 Oct 6;193(1):155-61. doi: 10.1007/BF00221608.
Estradiol benzoate was injected into virgin rats, at a concentration of 50 microgram/day, for 7 days. The animals were fixed by perfusion and the mammary glands prepared for electron microscopy. Many myoepithelial cells in the mammary glands were altered as a result of the estradiol treatment. The affected cells had a markedly reduced number of myofilaments that were restricted to a specific region of the cytoplasm. Large foot-like projections with many vesicles extended from the myoepithelial cells into the surrounding connective tissue. The altered cells also had more organelles, suggesting that their metabolic activity was increased. Nuclei in the altered cells had deep infoldings that may reflect an increase in nuclear/cytoplasmic exchanges. The results of this study indicate that estradiol causes specific morphological alterations in myoepithelial cells of the mammary gland.
将苯甲酸雌二醇以50微克/天的浓度注射到未孕大鼠体内，持续7天。通过灌注固定动物，并制备乳腺用于电子显微镜检查。由于雌二醇处理，乳腺中的许多肌上皮细胞发生了改变。受影响的细胞中肌丝数量明显减少，且局限于细胞质的特定区域。带有许多小泡的大的足状突起从肌上皮细胞延伸到周围的结缔组织中。发生改变的细胞也有更多的细胞器，这表明它们的代谢活性增加。发生改变的细胞中的细胞核有深深的褶皱，这可能反映了核/质交换的增加。本研究结果表明，雌二醇会导致乳腺肌上皮细胞发生特定的形态学改变。
