Bowles S M, Mills R J
Ann Clin Biochem. 1981 Jul;18(Pt 4):226-31. doi: 10.1177/000456328101800407.
The effect that synthetic steroid components of different oral contraceptives have on the assay system for measurement of sex hormones binding globulin (SHBG)-binding capacity, has been examined. Interference with the assay was not demonstrable at therapeutic levels of the drugs. d-Norgestrel was the only steroid studied which bound to SHBG with an affinity comparable to the endogenous sex hormones; it also tended to decrease SHBG-finding capacity, whereas preparations containing low levels of norethisterone increased the binding capacity. We suggest that measurement of changes in SHBG-binding capacity in subjects taking oral contraceptives may prove useful in indicating changes in sex hormone balance, particularly in view of the well-recognised side-effect of these drugs.
研究了不同口服避孕药的合成类固醇成分对性激素结合球蛋白（SHBG）结合能力测定系统的影响。在药物治疗水平下未发现对该测定有干扰。炔诺孕酮是所研究的唯一一种与SHBG结合亲和力与内源性性激素相当的类固醇；它还倾向于降低SHBG结合能力，而含有低水平炔诺酮的制剂则增加结合能力。我们认为，测定服用口服避孕药的受试者的SHBG结合能力变化，可能有助于表明性激素平衡的变化，特别是鉴于这些药物广为人知的副作用。
