Harkness D R, Byrnes J J, Lian E C, Williams W D, Hensley G T
JAMA. 1981;246(17):1931-3.
A patient with thrombotic thrombocytopenic purpura (TTP) showed for the first time catastrophic signs and symptoms of CNS involvement immediately after infusion of platelets. Postmortem examination revealed extensive deposits of platelet aggregates within the small blood vessels of the brain, whereas lesions elsewhere in the body consisted of platelets as well as fibrin and were associated with endothelial proliferation and microaneurysm formation. These findings are consistent with the view that the initial event in TTP may be platelet aggregation. The plasma of this patient contained platelet-aggregating activity. We conclude that platelet transfusions in patients with TTP may aggravate the disease process.
一名血栓性血小板减少性紫癜（TTP）患者在输注血小板后立即首次出现中枢神经系统受累的灾难性体征和症状。尸检显示脑内小血管中有大量血小板聚集体沉积，而身体其他部位的病变由血小板以及纤维蛋白组成，并伴有内皮细胞增殖和微动脉瘤形成。这些发现与TTP的初始事件可能是血小板聚集的观点一致。该患者的血浆含有血小板聚集活性。我们得出结论，TTP患者输注血小板可能会加重疾病进程。
