Rondeau D B, Young L, Hebert D, Trottier B L
Neurobehav Toxicol Teratol. 1981 Fall;3(3):313-9.
A battery of tests was used to assess the neurobehavioral effects of fenitrothion in doses of 10, 20 and 40 mg/kg administered daily to rats for a period of 40 days. Decreases in body weight, overt cholinergic signs, loss of many reflexes, changes in measures of motor activity and, later, indices of ataxia were observed at various times after onset of treatment with the two higher doses of fenitrothion. Mortalities occurred within 12 days in those groups but all signs of toxicity and of behavioral deficits disappeared gradually in survivors. Changes in the neurobehavioral measures were seen in only two of the animals treated with 10 mg/kg and only after more than 20 days of treatment; in one rat, weight loss, absence of some reflexes, deficits in activity and signs of ataxia preceded death by several days. Results are discussed in relation with the existing data on the behavioral toxicity of fenitrothion.
采用一系列测试评估了对硫磷对大鼠的神经行为影响。对大鼠每日给予剂量为10、20和40毫克/千克的对硫磷，持续40天。在用两种较高剂量的对硫磷治疗开始后的不同时间，观察到体重减轻、明显的胆碱能体征、许多反射消失、运动活动指标变化以及后来的共济失调指标变化。在这些组中，12天内出现死亡，但幸存者中所有毒性和行为缺陷的迹象逐渐消失。仅在接受10毫克/千克治疗的两只动物中观察到神经行为指标的变化，且仅在治疗20多天后出现；在一只大鼠中，体重减轻、一些反射消失、活动缺陷和共济失调迹象在死亡前几天出现。结合现有的关于对硫磷行为毒性的数据对结果进行了讨论。
