Maunuksela E L, Gattiker R I
Anesth Analg. 1981 Nov;60(11):798-801.
Dosage of pancuronium required to produce 90% neuromuscular blockade, time of onset of action of pancuronium and changes in heart rate and arterial pressure were evaluated in 30 children with congenital cardiovascular disease during intravenous anesthesia. Neuromuscular blockade was measured using train-of-four stimulation (2 Hz for 2 seconds) and twitch count. The 90% blockade was defined as being one twitch felt on the stretched abducted thumb. In 10 children given 0.03- to 0.01-mg/kg increments of pancuronium at 2-minute intervals the mean (+/-SD) dose required to produce 90% neuromuscular blockade was 0.10 +/- 0.02 mg/kg with a range from 0.08 to 0.14 mg/kg. In 20 children given 0.1 mg/kg of pancuronium, 90% neuromuscular blockade was achieved in 4.45 +/- 1.58 minutes. Children less than 2 years of age did not differ from the older children nor did cyanotic children differ from the acyanotic children. There were no significant changes in heart rate or arterial pressure. In one case bigeminy during intubation was seen. No children had tachycardia after pancuronium.
在30例先天性心血管疾病患儿静脉麻醉期间，评估了产生90%神经肌肉阻滞所需的泮库溴铵剂量、泮库溴铵的起效时间以及心率和动脉压的变化。使用四个成串刺激（2Hz，持续2秒）和颤搐计数来测量神经肌肉阻滞。90%阻滞定义为在外展伸直的拇指上感觉到一次颤搐。在10例以2分钟间隔给予0.03至0.01mg/kg递增剂量泮库溴铵的患儿中，产生90%神经肌肉阻滞所需的平均（±标准差）剂量为0.10±0.02mg/kg，范围为0.08至0.14mg/kg。在20例给予0.1mg/kg泮库溴铵的患儿中，4.45±1.58分钟达到90%神经肌肉阻滞。2岁以下患儿与大龄患儿无差异，青紫型患儿与非青紫型患儿也无差异。心率或动脉压无显著变化。有1例在插管期间出现二联律。给予泮库溴铵后无患儿出现心动过速。
