[Effect of stimulation and destruction of the substantia nigra on phenamine- and apomorphine-induced stereotypy in cats].

Electrical stimulation of substantia nigra enhances the behavioral and electroencephalographic parameters of the stereotypy induced by threshold doses of amphetamine (0.5 and 1 mg/kg) but does not produce any effect on apomorphine action (2 and 5 mg/kg). Bilateral electrolytic destruction of the brain structure, on the contrary, reduces the action of amphetamine, especially in the early postoperative period. At the same time the intensity of the apomorphine-induced stereotypy rises. It is concluded that the increased activity of substantia nigra is of crucial significance in the genesis of the amphetamine-induced stereotypy. Meanwhile the effect of apomorphine may be realized without direct participation of the brain structure under consideration.