Nonchev S G, Koniukhov B V
Genetika. 1981;17(10):1798-804.
Results concerning interaction between the genes blind (Bld) and ocular retardation (or) during mouse embryogenesis are presented. It was established that in Bld/+ or/or mice the Bld gene effects are not expressed, as a result of the pronounced eye reduction caused by the or gene action. In Bld/+ or/or embryos the phenocritic stage of the Bld gene action is deplaced to more early embryogenesis period than that in the Bld/+ +/+ embryos. This leads to the recessive epistasis of the or gene over the Bld gene. The analysis of gene interaction has also indicated that the lid mesodermal component growth is the primary target process affected by the Bld/+ constitution.
本文展示了关于小鼠胚胎发育过程中盲眼（Bld）基因与眼发育迟缓（or）基因之间相互作用的研究结果。已证实，在Bld/+ or/or小鼠中，由于or基因作用导致明显的眼睛发育不全，Bld基因的效应未得到表达。在Bld/+ or/or胚胎中，Bld基因作用的表型临界期比Bld/+ +/+胚胎的相应时期提前至更早的胚胎发育阶段。这导致or基因对Bld基因为隐性上位作用。基因相互作用分析还表明，眼睑中胚层成分的生长是受Bld/+基因型影响的主要靶标过程。
