Mason B A, Dambra J, Grossman B, Catalano R B
Cancer Treat Rep. 1982 Feb;66(2):243-5.
Seventy-three consecutive patients receiving cisplatin-containing chemotherapy regimens were treated with an initial dose of chlorpromazine (25 mg im), droperidol (1 mg iv, then 1 mg sc every 4 hours), and methylprednisolone (250 mg every 4 hours for four doses). Twenty patients received a combination chemotherapy protocol that included cisplatin at a dose of 40 mg/m2 iv (group 1) and 53 patients received a protocol that included cisplatin at a dose of 120 mg/m2 iv (group 2). The median age of all the patients was 58 years. Seventy-five percent of the patients in group 1 and 45% of those in group 2 had no vomiting at all; the remainder had limited and tolerable vomiting. These results in a group of elderly patients compare favorably with trials of other antiemetic programs.
73例接受含顺铂化疗方案的连续患者，初始接受氯丙嗪（25mg，肌肉注射）、氟哌利多（1mg，静脉注射，然后每4小时皮下注射1mg）和甲泼尼龙（每4小时250mg，共4剂）治疗。20例患者接受了包含40mg/m²顺铂静脉注射的联合化疗方案（第1组），53例患者接受了包含120mg/m²顺铂静脉注射的方案（第2组）。所有患者的中位年龄为58岁。第1组75%的患者和第2组45%的患者完全没有呕吐；其余患者呕吐有限且可耐受。在一组老年患者中的这些结果与其他止吐方案的试验相比具有优势。
