乙醇中毒作为三种近交系小鼠品系中基因型依赖性反应的函数。
Ethanol intoxication as a function of genotype dependent responses in three inbred mice strains.
作者信息
Elston S F, Blum K, DeLallo L, Briggs A H
出版信息
Pharmacol Biochem Behav. 1982 Jan;16(1):13-5. doi: 10.1016/0091-3057(82)90005-3.
PMID:7199182
Abstract
Three strains of mice, ICR Swiss, DBA/2J and C57Bl/6J were compared for initial sensitivity, recovery from intoxication, and acute tolerance development to ethanol. The The C57Bl/6J mice were found to be less sensitive and to recover more rapidly from the effects of the same dose of ethanol than the other two strains treated. None of the strains tested demonstrated acute tolerance to ethanol when given the same dose 3 hours later.
摘要
比较了三种品系的小鼠，即ICR瑞士小鼠、DBA/2J小鼠和C57Bl/6J小鼠对乙醇的初始敏感性、中毒恢复情况以及急性耐受性发展。发现C57Bl/6J小鼠比其他两种受试品系对相同剂量乙醇的敏感性更低，且从乙醇作用中恢复得更快。当在3小时后给予相同剂量时，所测试的品系中没有一个表现出对乙醇的急性耐受性。
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