Belknap J K, Belknap N D, Berg J H, Coleman R
Behav Genet. 1977 Nov;7(6):413-25. doi: 10.1007/BF01066776.
Experimentally naive male mice of both strains were exposed to a two-bottle choice situation (ethanol vs. water) and their drinking behavior was observed during the first hour. DBA/2J mice developed a significant avoidance of 2% or 10% ethanol during the first 10 min. At 15 and 60 min following introduction of the bottles, no DBA mouse exhibited more than a 6 mg% blood ethanol level while all of the C57BL mice exceeded this concentration. Significant postabsorptive effects in the DBA mice seem unlikely at these very low blood ethanol values. Animals of both strains were examined for their ability to form lithium-induced conditioned taste aversions to 2% ethanol or 15% sucrose solutions. DBA mice readily formed conditioned aversions to both solutions, but the C57BL strain significantly avoided only the sucrose. C57BL mice appear to have difficulty in discriminating the 2% ethanol from distilled water. The neural sensitivity to ethanol was examined in both strains using the sleep time test and the grid test. C57BL mice were significantly more sensitive than DBA mice in both tests.
两种品系的未经过实验的雄性小鼠被置于双瓶选择情境（乙醇与水）中，并在最初一小时观察它们的饮水行为。DBA/2J小鼠在最初10分钟内对2%或10%的乙醇表现出显著的回避。在引入瓶子后的15分钟和60分钟时，没有一只DBA小鼠的血液乙醇水平超过6mg%，而所有C57BL小鼠的血液乙醇水平都超过了这个浓度。在这些非常低的血液乙醇值下，DBA小鼠不太可能出现明显的吸收后效应。对两种品系的动物进行了测试，以考察它们形成锂诱导的对2%乙醇或15%蔗糖溶液的条件性味觉厌恶的能力。DBA小鼠很容易对两种溶液形成条件性厌恶，但C57BL品系只对蔗糖有明显的回避。C57BL小鼠似乎难以区分2%的乙醇和蒸馏水。使用睡眠时间测试和网格测试考察了两种品系对乙醇的神经敏感性。在这两种测试中，C57BL小鼠都比DBA小鼠更敏感。
