Hess H
Arzneimittelforschung. 1981;31(11a):2032-5.
The dynamic balance between the vessel wall and the systems of the platelets, of coagulation and of the fibrinolysis, termed vessel wall-blood homoiostasis, can be altered in a physiologically suitable way as well as pathologically. A disturbance of the vessel wall-blood homoiostasis is considered the key process of the pathogenesis of all obliterating angiopathies. This view can explain why different risk factors may lead to the same picture of obliterative arteriosclerosis. From this point of view practical consequences for the treatment arise which may - under most favorable circumstances - render a restitution and integrum possible or at least a regression of obliterative processes.
血管壁与血小板系统、凝血系统和纤维蛋白溶解系统之间的动态平衡，即血管壁-血液稳态，可在生理上适当的方式以及病理情况下发生改变。血管壁-血液稳态的紊乱被认为是所有闭塞性血管病发病机制的关键过程。这一观点可以解释为什么不同的危险因素可能导致相同的闭塞性动脉硬化表现。从这一观点出发，产生了对治疗的实际影响，在最有利的情况下，这些影响可能使恢复和完整成为可能，或者至少使闭塞过程有所消退。
