某些喹唑啉酮的单胺氧化酶抑制作用及中枢神经系统活性
Monoamine oxidase inhibitory and CNS activities of some quinazolinones.
作者信息
Lata A, Satsangi R K, Srivastava V K, Kishor K
出版信息
Arzneimittelforschung. 1982;32(1):24-7. doi: 10.1002/chin.198221223.
PMID:7199337
Abstract
16 new compounds have been synthesised in the series of 3-aryl-2-(1'-aryl-piperazin-4'-yl-carboxamidomethyl)-mercapto-quinazolinones. The compounds showed interesting results in anticonvulsant, hypnotic and monoamine oxidase (MAO) inhibitory screenings and are non-toxic. SAR were evaluated.
摘要
在3-芳基-2-(1'-芳基-哌嗪-4'-基-甲酰胺基甲基)-巯基-喹唑啉酮系列中已合成了16种新化合物。这些化合物在抗惊厥、催眠和单胺氧化酶（MAO）抑制筛选中显示出有趣的结果，且无毒。对构效关系进行了评估。
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