Heuer L J
Arzneimittelforschung. 1982;32(1):32-4.
In normocalcemic fasted rats the effect of synthetic salmon calcitonin (Calcitonin-Sandoz) at a dose of 0.1 ml/kg b.w. (= 10 IU/kg b.w.) on the absorption of 45Ca was evaluated by investigating its radioactivity in the blood from the tailtip up to 120 min after intragastric administration of 4.0 microCi 45CaCl2. Measurement of the radioactivity in the serum of the rats was started 90 min after the application of calcitonin. Salmon calcitonin inhibited the gastroenteral absorption of 45Ca by ca. 49%. There was a decrease in stable serum calcium level by 13% (from 2.46 to 2.15 mmol/l) during 3 1/2 h observation.
在血钙正常的禁食大鼠中，通过在胃内给予4.0微居里氯化钙后，检测尾尖血液中直至120分钟的放射性，评估了剂量为0.1毫升/千克体重（=10国际单位/千克体重）的合成鲑鱼降钙素（降钙素-山德士）对45钙吸收的影响。在给予降钙素90分钟后开始测量大鼠血清中的放射性。鲑鱼降钙素使45钙的胃肠吸收约抑制了49%。在3.5小时的观察期内，稳定的血清钙水平下降了13%（从2.46毫摩尔/升降至2.15毫摩尔/升）。
