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同卵三胞胎:会出现不同的精神病症状吗?

Identical triplets: non-identical psychosis?

作者信息

McGuffin P, Reveley A, Holland A

出版信息

Br J Psychiatry. 1982 Jan;140:1-6. doi: 10.1192/bjp.140.1.1.

Abstract

In contrast to all previous reports of psychoses in genetically identical siblings, identical triplets aged 28 were discordant by major Kraepelinian type of psychosis. Two of them had been diagnosed schizophrenic while the third was diagnosed manic depressive. Re-evaluation of their illnesses using standardized methods and diagnosis by blind raters suggested that the discordance was not due to simple misdiagnosis or different diagnostic bias between psychiatrists. These triplets illustrate some of the shortcomings of a strictly applied Kraepelinian dichotomy and show that a genetic perspective is important in attempting to resolve the classificatory problems of atypical psychoses.

摘要

与之前所有关于基因相同的兄弟姐妹患精神病的报告不同,28岁的同卵三胞胎在主要的克雷佩林式精神病类型上存在不一致。其中两人被诊断为精神分裂症,而第三人被诊断为躁郁症。使用标准化方法对他们的疾病进行重新评估,并由不知情的评估者进行诊断,结果表明这种不一致并非由于简单的误诊或精神科医生之间不同的诊断偏差。这些三胞胎说明了严格应用克雷佩林二分法的一些缺点,并表明从遗传学角度来看,对于试图解决非典型精神病的分类问题很重要。

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