Blackwood D, St Clair D, Muir W
University Department of Psychiatry, Royal Edinburg Hospital, UK.
Eur Arch Psychiatry Clin Neurosci. 1991;240(3):191-6. doi: 10.1007/BF02190763.
A family is reported in which the monozygotic co-twin of a schizophrenic proband was diagnosed bipolar 1 and their mother had a history of unipolar major depression. Although their clinical manifestations varied, the ill members of this family shared an abnormality in P300 not found in the asymptomatic siblings. In 14 families, linkage to the 5q11-13 region was excluded when affection status was defined solely by P300 latency independently of the clinical findings. Linkage was also excluded when the analysis was restricted to the families that had no cases of bipolar illness and when the schizophrenic phenotype was narrowly or broadly defined. It is concluded that biological markers such as P300 and eye tracking may help to clarify the overlap of different types of psychosis and help to define the phenotype for linkage analyses.
据报道，一个家庭中，精神分裂症先证者的同卵双生子被诊断为双相I型障碍，且他们的母亲有单相重度抑郁症病史。尽管他们的临床表现各不相同，但该家庭的患病成员在P300上存在一种无症状兄弟姐妹未发现的异常。在14个家庭中，当仅根据P300潜伏期定义患病状态而不考虑临床发现时，排除了与5q11 - 13区域的连锁关系。当分析仅限于没有双相情感障碍病例的家庭，以及对精神分裂症表型进行狭义或广义定义时，也排除了连锁关系。结论是，诸如P300和眼动追踪等生物学标记可能有助于阐明不同类型精神病的重叠情况，并有助于为连锁分析定义表型。
