使用不同药物治疗高催乳素血症：一项关于溴隐亭、美麦角林和利舒脲的研究。

Treatment of hyperprolactinemic states with different drugs: a study with bromocriptine, metergoline, and lisuride.

作者信息

Crosignani P G, Ferrari C, Liuzzi A, Benco R, Mattei A, Rampini P, Dellabonzana D, Scarduelli C, Spelta B

出版信息

Fertil Steril. 1982 Jan;37(1):61-7. doi: 10.1016/s0015-0282(16)45978-9.

PMID:7199483

Abstract

One hundred ninety-one hyperprolactinemic patients (78 women and 13 men; 54 with pituitary macroadenoma, 53 with microadenoma, and 84 with idiopathic disease) were treated for 2 to 48 months with one or two of the following prolactin (PRL)-lowering drugs: bromocriptine, metergoline, and lisuride. All of the three drugs used were highly effective in lowering PRL levels and restoring gonadal function both in females and in males in the majority of patients with either idiopathic or tumorous disease. In poorly responsive patients, increasing the drug doses resulted in further PRL lowering for all the three drugs. Mild side effects were frequently encountered with initiation of drug treatment but spontaneously subsided in most cases; severe side effects, necessitating stopping of the treatment, occurred in only 12 instances, but changing of the drug allowed PRL-lowering treatment to be continued in 11 of them.

摘要

191例高催乳素血症患者（78例女性，13例男性；54例患有垂体大腺瘤，53例患有微腺瘤，84例患有特发性疾病）接受了以下一种或两种降低催乳素（PRL）的药物治疗，疗程为2至48个月：溴隐亭、麦角乙脲和利舒脲。在大多数患有特发性或肿瘤性疾病的患者中，所使用的这三种药物在降低女性和男性的PRL水平以及恢复性腺功能方面均非常有效。在反应欠佳的患者中，增加药物剂量可使这三种药物进一步降低PRL水平。开始药物治疗时经常会出现轻微副作用，但在大多数情况下会自行消退；严重副作用导致治疗停止的情况仅发生了12例，但其中11例通过更换药物得以继续进行PRL降低治疗。