Zadik Z, de Lacerda L, Kowarski A A
J Clin Endocrinol Metab. 1982 May;54(5):1072-4. doi: 10.1210/jcem-54-5-1072.
The diagnostic value of the 24-h integrated concentration (IC) test of cortisol (IC-24-F) was found to be superior to the value of both urinary 17OHCS and urinary free-cortisol tests. The IC-24-F test is too cumbersome for widespread clinical use. The purpose of the present study was to evaluate the diagnostic value of an abbreviated and practical 6-h IC of cortisol (IC-6-F) test. The IC of cortisol (IC-F) was measured in 68 normal subjects and 13 patients with surgically proven Cushing's syndrome. A portable nonthrombogenic constant blood withdrawal system was used over a 24-h period. The IC-F was measured in plasma withdrawn during each 1/2-h period (IC-1/2-F). The mean of 12 consecutive measurements of IC-1/2-F yielded the IC-6-F. The mean of all the IC-1/2-F collected over a 24-h period constituted the IC-24-F. The IC-1/2-F of the patients and their IC-6-F from 0800-1400 h, 1400-2000 h, and 2000-0200 h overlapped the corresponding levels in the control subjects. There was no overlap between the IC-24-F and the IC-6-F (from 2000-0200 h) of the patients and the control subjects. It was concluded that the diagnostic value of a 6-h IC-F test conducted during the afternoon and early part of the might is equal to the diagnostic value of the 24-h IC-F test.
研究发现，皮质醇24小时整合浓度（IC）检测（IC-24-F）的诊断价值优于尿17羟皮质类固醇和尿游离皮质醇检测。IC-24-F检测操作过于繁琐，不适合广泛用于临床。本研究的目的是评估简化实用的皮质醇6小时IC检测（IC-6-F）的诊断价值。对68名正常受试者和13例经手术证实为库欣综合征的患者进行了皮质醇IC（IC-F）检测。在24小时内使用便携式非血栓形成恒速采血系统。在每半小时采集的血浆中测量IC-F（IC-1/2-F）。连续12次测量IC-1/2-F的平均值得出IC-6-F。24小时内采集的所有IC-1/2-F的平均值构成IC-24-F。患者的IC-1/2-F及其在08:00 - 14:00、14:00 - 20:00和20:00 - 02:00的IC-6-F与对照受试者的相应水平重叠。患者和对照受试者的IC-24-F与IC-6-F（20:00 - 02:00）之间没有重叠。得出的结论是，在下午和夜间早期进行的6小时IC-F检测的诊断价值与24小时IC-F检测的诊断价值相当。
