Maj J
Pharmacopsychiatria. 1982 Jan;15(1):26-30. doi: 10.1055/s-2007-1019505.
The psychopharmacological profile and mechanism of action of ten atypical novel and potential antidepressive drugs (AD) have been investigated. It has been shown that they form a pharmacologically heterogeneous group. Some of them may be considered as central 5-hydroxytryptamine (5-HT) antagonists. Two typical AD, amitriptyline and doxeprine, turned out to be potent 5-HT antagonists also. These observations justify the conclusion that these drugs rather block than facilitate 5-HT neurotransmission. Some data indicate that 5-HT antagonists can shift the balance between the noradrenergic and serotoninergic systems in favour of the former. Both atypical and typical AD when administered chronically, induce effects not observed after single-dose treatment. The effects observed indicate that the chronic administration of AD leads to the development of the increased responsiveness (or activation) of the noradrenergic system.
已对十种非典型新型潜在抗抑郁药物（AD）的精神药理学特征及作用机制进行了研究。结果表明，它们构成了一个药理学上异质性的组群。其中一些药物可被视为中枢5-羟色胺（5-HT）拮抗剂。两种典型的抗抑郁药，即阿米替林和多塞平，也被证明是强效的5-HT拮抗剂。这些观察结果证明了这样一个结论，即这些药物是阻断而非促进5-HT神经传递。一些数据表明，5-HT拮抗剂可使去甲肾上腺素能系统和5-羟色胺能系统之间的平衡朝着有利于前者的方向转变。非典型和典型抗抑郁药长期给药时，会产生单剂量治疗后未观察到的效应。观察到的效应表明，抗抑郁药的长期给药会导致去甲肾上腺素能系统反应性增加（或激活）。
