Yang J C, Clark W C, Dooley J C, Mignogna F V
Anesth Analg. 1982 Apr;61(4):358-61.
Sixteen healthy male volunteers had 30 mg of cocaine HCI solution or normal saline placebo impregnated in cotton-covered applicators administered intranasally on different days in a double-blind procedure. Ischemic tourniquet pain was significantly less after cocaine than it was in pretreatment control. It was also significantly less than after administration of a placebo. Responses to questionnaires concerning subjective drug effects, mood, and alertness revealed little change in psychological status associated with either cocaine or placebo. Thus, the reported decrease in pain was probably not caused by a change in affect or by altered consciousness. These results indicate that, in addition to its known properties as a local aesthetic, cocaine when applied intranasally exerts an analgesic effect.
16名健康男性志愿者参与了一项双盲实验，在不同日期通过鼻腔给予他们浸泡有30毫克盐酸可卡因溶液或生理盐水安慰剂的棉球涂抹器。与预处理对照组相比，使用可卡因后缺血性止血带疼痛明显减轻。同时，其疼痛程度也显著低于服用安慰剂后。关于主观药物效果、情绪和警觉性的问卷调查结果显示，使用可卡因或安慰剂后心理状态变化不大。因此，报告中疼痛减轻可能并非由情感变化或意识改变所致。这些结果表明，除了已知的局部麻醉特性外，鼻腔内使用可卡因还具有镇痛作用。
