Buyukmihci N, Goehring-Harmon F, Marsh R F
J Comp Neurol. 1982 Feb 10;205(1):49-54. doi: 10.1002/cne.902050105.
Hamsters experimentally inoculated with scrapie had histologic and ultrastructural changes in their retinas before clinical signs of central nervous system disease became evident at 50 days postinoculation. The retinal changes were limited to the photoreceptors and began with degenerative changes in the inner segments as early as 8 days postinoculation. As the inner segment lesions became more prominent, associated degenerative changes within outer segments were seen (38 days postinoculation). An influx of macrophages was associated with increasing degenerative changes; these cells engulfed cellular debris did not appear to contribute directly to the degenerative process. Retinas having the greatest damage to the inner segment area also had moderate reduction in outer nuclear layer density and outer segment length, and in numbers of outer segments. All of the retinal changes described occurred almost exclusively in the central to mid-region of retina with relative sparing of peripheral retina.
实验性接种羊瘙痒病的仓鼠，在接种后50天中枢神经系统疾病的临床症状明显出现之前，其视网膜就已经出现了组织学和超微结构变化。视网膜变化仅限于光感受器，早在接种后8天内节段就开始出现退行性变化。随着内节段病变变得更加突出，外节段内也出现了相关的退行性变化（接种后38天）。巨噬细胞的流入与退行性变化的增加有关；这些吞噬细胞碎片的细胞似乎没有直接促成退行性过程。内节段区域受损最严重的视网膜，其外核层密度、外节段长度和外节段数量也有适度减少。所描述的所有视网膜变化几乎都只发生在视网膜的中央到中部区域，周边视网膜相对未受影响。
