环境温度对吗啡身体依赖性和戒断反应的差异效应。

Differential effect of environmental temperature on morphine physical dependence and abstinence.

Beckman A L, Llados-Eckman C, Stanton T L, Adler M W

Life Sci. 1982 Mar 22;30(12):1013-20. doi: 10.1016/0024-3205(82)90519-7.

Abstract

Ambient temperature (Ta) significantly influenced the display of 4 of the 14 naloxone-precipitated withdrawal signs (nesting, flat posture, vocalization, dyspnea) in morphine-dependent, non-hibernating ground squirrels (Citellus lateralis). 2) Analysis of variance performed on the six quantified signs revealed that Ta during withdrawal, but not during the development of physical dependence, was a significant factor in determining the expression of two signs (nesting and vocalization). 3) The interaction between the influence of Ta during the periods of morphine administration and abstinence was a significant factor in determining the expression of nesting behavior, a finding that is consistent with the natural role of nesting as a behavioral thermoregulatory response. 4) We conclude that environmental temperature modulates the expression of selected components of the naloxone-precipitated abstinence syndrome in C. lateralis without exerting a measurable influence on the development of morphine physical dependence itself.

摘要

环境温度（Ta）显著影响了吗啡依赖、非冬眠地松鼠（侧纹黄鼠）的14种纳洛酮诱发戒断症状中的4种（筑巢、平卧位姿势、发声、呼吸困难）的表现。2) 对六种量化症状进行的方差分析显示，戒断期间而非身体依赖形成期间的Ta是决定两种症状（筑巢和发声）表现的重要因素。3) 吗啡给药期和戒断期Ta的影响之间的相互作用是决定筑巢行为表现的重要因素，这一发现与筑巢作为行为性体温调节反应的自然作用一致。4) 我们得出结论，环境温度调节侧纹黄鼠纳洛酮诱发戒断综合征选定成分的表现，而对吗啡身体依赖本身的形成没有可测量的影响。