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[基于密码子碱基结构物理预定假说可预测的遗传密码进化变化]

[Evolutionary changes in the genetic code, predictable on basis of the hypothesis of physical predetermination of the structure of codon bases].

作者信息

Sukhodolets V V

出版信息

Genetika. 1982 Mar;18(3):499-502.

PMID:7200441
Abstract

According to the earlier proposed hypothesis on the structural correspondence between amino acids and doublets from the first codon bases (Sukhodolets 1980), the UGA triplet corresponds to tryptophan and the AGX triplets - to the termination codons. It is notably this sense of the UGA and AGA, AGG, respectively, that was reported for mitochondrial codes. Thereby, a proposal is indirectly confirmed that meanings of the UGA (nonsense) and AGA, AGG (arginine) in the normal cytoplasmic code is the result of evolutionary changes.

摘要

根据先前提出的关于氨基酸与第一个密码子碱基中的双联子之间结构对应关系的假说(苏霍多列茨,1980年),UGA三联体对应色氨酸,而AGX三联体对应终止密码子。线粒体密码中UGA和AGA、AGG的含义尤其正是如此。从而,一个提议得到了间接证实,即在正常细胞质密码中UGA(无义)以及AGA、AGG(精氨酸)的含义是进化变化的结果。

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