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Meperidine metabolism in the parturient.

作者信息

Morrison J C, Todd E L, Lipshitz J, Anderson G D, Schneider J M, Dilts P V

出版信息

Obstet Gynecol. 1982 Mar;59(3):359-65.

PMID:7200592
Abstract

A study of meperidine metabolism was undertaken in 21 normal parturients at term. Meperidine, 50 mg intravenously, was the sole analgesic agent used during the intrapartum period. Maternal and cord blood assessment for meperidine and normeperidine was done by gas chromatography-mass spectrophotometry. Most maternal sera showed a typical meperidine elimination curve. A secondary rise in maternal meperidine 30 to 180 minutes after injection was found in 4 patients. One patient showed a significant alteration in normeperidine appearance. These data add further validity to the hypothesis that the pregnant woman can metabolize meperidine by several pathways.

摘要

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引用本文的文献

1
[Systemic analgesia during labour.].
Schmerz. 1994 Mar;8(1):5-11. doi: 10.1007/BF02527504.