Winkler C, Burgener L, Ehmann R
Z Geburtshilfe Perinatol. 1982 Feb;186(1):1-8.
Eight cases of materno-fetal listeriosis were discovered at the University Women's Hospital of Basel from May 1977 until June 1980. This represent an incidence of 0,15% of all births. This infectious disease has often a fatal course for the unborn child, therefore it is important to know the clinical manifestations occurring with it. Listeriosis during pregnancy has a typical-two-stage course: During the first phase we see commonly a flu-like illness abating rapidly, about two weeks later fever starts again and premature contractions ensue, but no therapy is successful in controlling the fever and the premature labour. The usual fate for the unborn child is stillbirth or premature delivery with subsequent neonatal death due to prematurity, RDS, sepsis and meningitis. The low fetal and neonatal survival rate can be improved by two relatively simple measures: 1) a high index of suspicion with early diagnosis, 2) an early treatment with ampicillin either in the antepartal or neonatal stage. We review the epidemiology, the bacteriology, the serology and the histo-pathology of this relatively rare but important disease during pregnancy.
1977年5月至1980年6月期间，巴塞尔大学妇女医院发现了8例母婴李斯特菌病病例。这占所有分娩病例的0.15%。这种传染病对未出生的孩子往往是致命的，因此了解其临床表现很重要。妊娠期李斯特菌病有一个典型的两阶段病程：在第一阶段，我们通常会看到类似流感的疾病迅速缓解，大约两周后再次发热，并出现早产宫缩，但没有治疗方法能成功控制发热和早产。未出生孩子的通常结局是死产或早产，随后因早产、呼吸窘迫综合征、败血症和脑膜炎导致新生儿死亡。通过两个相对简单的措施可以提高胎儿和新生儿的低存活率：1）高度怀疑并早期诊断；2）在产前或新生儿期尽早使用氨苄青霉素治疗。我们回顾了这种妊娠期相对罕见但重要疾病的流行病学、细菌学、血清学和组织病理学。
