Köpp W, Vogel M
Z Geburtshilfe Perinatol. 1982 Feb;186(1):37-40.
Twenty placentas of mothers addicted to heroin were examined macroscopically, microscopically and morphometrically. Twenty placentas of non-addicted mothers and of the same gestational age served as a control group. The following, statistically documented, peculiarities were found in the placentas of mothers addicted to heroin: 1) increased intervillous and perivillous microfibrin deposits; 2) an increased number of trophoblastic proliferation buds and nuclear nodules; 3) increased vascularization of the villi, and 4) increased signs of asphyxia. Our findings support the view, mentioned in the literature, that fetal hypotrophy is probably the result of a direct action of the heroin on the fetal tissue. We regard the placental changes as secondary effects of circulation complications in heroin addicts.
对20例吸食海洛因母亲的胎盘进行了大体、显微镜及形态计量学检查。选取20例相同孕周未吸食海洛因母亲的胎盘作为对照组。在吸食海洛因母亲的胎盘中发现了以下有统计学记录的特点：1）绒毛间隙和绒毛周围微纤维蛋白沉积增加；2）滋养层增殖芽和核结节数量增加；3）绒毛血管化增加；4）窒息迹象增加。我们的研究结果支持文献中提到的观点，即胎儿发育迟缓可能是海洛因直接作用于胎儿组织的结果。我们认为胎盘变化是海洛因成瘾者循环系统并发症的继发效应。
