Coulam C B, Annegers J F, Kranz J S
Am J Obstet Gynecol. 1982 Jun 1;143(3):319-24. doi: 10.1016/0002-9378(82)90821-3.
A cohort of 487 patients with chronic anovulation syndrome diagnosed between January 1, 1970, and January 1, 1980, were followed up to determine the frequency of pituitary adenomas among them. Of the 487 patients, four (0.8%) had pituitary adenoma. This compares with an expected number of 0.42, yielding a relative risk of 9.5 (95% confidence interval, 2.6 to 24.3). Within this cohort, the prevalence rate was 2.7% for galactorrhea and 3.3% for hyperprolactinemia. The prevalence rate of abnormal radiologic findings was 6.4% for roentgenography of the sella, 25.4% for sellar tomography, and 14.7% for computed tomography. In addition, 15 patients with pituitary adenomas and 60 control subjects were compared for prior anovulation syndrome. The relative risk of pituitary adenomas for patients with chronic anovulation syndrome in this case-control study was 24.3 (95% confidence interval, 4.9 to 120.6).
对1970年1月1日至1980年1月1日期间诊断为慢性无排卵综合征的487例患者进行随访，以确定其中垂体腺瘤的发生率。在这487例患者中，有4例（0.8%）患有垂体腺瘤。这与预期的0.42例相比，相对风险为9.5（95%置信区间为2.6至24.3）。在该队列中，溢乳的患病率为2.7%，高泌乳素血症的患病率为3.3%。蝶鞍X线摄影的异常影像学表现患病率为6.4%，蝶鞍断层扫描为25.4%，计算机断层扫描为14.7%。此外，对15例垂体腺瘤患者和60例对照受试者的既往无排卵综合征情况进行了比较。在这项病例对照研究中，慢性无排卵综合征患者患垂体腺瘤的相对风险为24.3（95%置信区间为4.9至120.6）。
