Brown R W, Meehan C, Martin F I, Bhathal P S
Cancer. 1982 Jul 1;50(1):125-9. doi: 10.1002/1097-0142(19820701)50:1<125::aid-cncr2820500123>3.0.co;2-d.
The histology of breast lumps in five patients with hyperprolactinemia showed benign mammary dysplasia with vacuolation of acinar and duct lining cells. In two cases, foci of lobular development resembling lactating breast tissue were also noted. In the past, focal secretory change has been considered to be idiopathic, but these cases indicate a possible association with hyperprolactinemia. Among other causes hyperprolactinemia may be a manifestation of occult pituitary adenoma. Therefore it is suggested that patients with benign breast nodules showing focal secretory change should be screened for clinical and laboratory evidence of hyperprolactinemia. Although it is accepted that in mice and rats prolactin plays an important role in chemically induced mammary tumorigenesis, a consensus has not been reached with regard to its role in man.
5例高催乳素血症患者乳腺肿块的组织学检查显示为良性乳腺发育异常，腺泡和导管内衬细胞有空泡形成。在2例中，还发现了类似哺乳期乳腺组织的小叶发育灶。过去，局灶性分泌改变被认为是特发性的，但这些病例表明可能与高催乳素血症有关。除其他原因外，高催乳素血症可能是隐匿性垂体腺瘤的一种表现。因此，建议对有局灶性分泌改变的良性乳腺结节患者进行筛查，以寻找高催乳素血症的临床和实验室证据。虽然人们公认催乳素在小鼠和大鼠化学诱导的乳腺肿瘤发生中起重要作用，但关于其在人类中的作用尚未达成共识。
