Venetz U, Willi P, Hirt A, Imbach P, Wagner H P
Helv Paediatr Acta. 1982;37(1):27-33.
In 12 of 95 children with idiopathic thrombocytopenic purpura (ITP) admitted to the Department of Pediatrics of the University Hospital in Bern between January 1st and December 31st 1979, the disease became chronic. Sex and age distribution were similar in children with acute and chronic ITP. Neither the history nor the initial symptomatology were useful for early detection of chronic ITP. For this purpose the initial raise of the platelet count after initiation of prednisone treatment appeared to be a more reliable parameter. Five of the 12 children received only drugs while 7 were splenectomized. After an observation period of 4 years none of 4 children who had received only drugs but 2 of 3 splenectomized children required intensive treatment. Prednisone and azathioprine, vincristine or cyclophosphamide, used alone or in various combinations, induced impressive but only temporary remissions.
1979年1月1日至12月31日期间，在伯尔尼大学医院儿科收治的95例特发性血小板减少性紫癜（ITP）患儿中，有12例病情转为慢性。急性和慢性ITP患儿的性别和年龄分布相似。病史和初始症状学对慢性ITP的早期检测均无帮助。为此，泼尼松治疗开始后血小板计数的初始升高似乎是一个更可靠的参数。12例患儿中5例仅接受药物治疗，7例行脾切除术。经过4年的观察期，4例仅接受药物治疗的患儿中无一例需要强化治疗，但3例脾切除患儿中有2例需要强化治疗。单独或联合使用泼尼松、硫唑嘌呤、长春新碱或环磷酰胺可诱导显著但仅为短暂的缓解。
