Schmitt H J, Eckstein K, Gutjahr P
Klin Padiatr. 1985 Sep-Oct;197(5):419-22. doi: 10.1055/s-2008-1034014.
The case histories of 79 children with idiopathic thrombocytopenic purpura (ITP) were retrospectively analyzed. The course was acute in 53 patients, chronic in 24, and recurrent in 2. In cases of acute ITP (aITP) the duration of disease in children who had received high-dose immunoglobulin therapy was on average 3.4 days shorter than in the untreated group, while in children who were given glucocorticoid therapy it was longer. Among the cases of chronic ITP, splenectomy in 5 out of 7 patients caused the thrombocyte count to return to normal, while in the other patients the increase was at least so high that there was no reason to fear the occurrence of hemorrhage. If the course is complicated in a case of chronic ITP, surgery should be considered, especially as the alternatives (glucocorticoids, high-dose immunoglobulin, vincristine) only led to a temporary success in our patients and hence only appear indicated in certain situations (e.g., when surgery is planned).
对79例特发性血小板减少性紫癜（ITP）患儿的病历进行回顾性分析。53例病程为急性，24例为慢性，2例为复发性。在急性ITP（aITP）病例中，接受大剂量免疫球蛋白治疗的儿童病程平均比未治疗组短3.4天，而接受糖皮质激素治疗的儿童病程则较长。在慢性ITP病例中，7例患者中有5例进行脾切除术后血小板计数恢复正常，而其他患者的血小板计数至少升高到不用担心出血发生的程度。如果慢性ITP病例的病程复杂，应考虑手术，特别是因为其他替代方法（糖皮质激素、大剂量免疫球蛋白、长春新碱）在我们的患者中仅取得了暂时成功，因此仅在某些情况下（例如计划进行手术时）才显得适用。
