Jeffreys R V, Napier J A, Reynolds S H
J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):264-6. doi: 10.1136/jnnp.45.3.264.
Using an in vitro bioassay, erythropoiesis stimulating activity has been measured in serum, cyst fluids and tumour homogenates from fourteen patients with cerebellar haemangioblastoma. Only two patients had elevated peripheral blood red cell counts and haemoglobin concentrations. Significantly elevated serum erythropoiesis stimulating activity was found in only one patient. High level, however, were detected in seven out of the fourteen cyst fluids and in the two homogenates tested. The dose response lines from these paralleled those of normal human erythropoietin. It was possible to neutralise the erythropoiesis stimulating activity in the cyst fluids with anti-human erythropoietin serum, indicating its similarity to erythropoietin, the normal erythropoietic regulating hormone. Significant release of the erythropoietic stimulating factor from the cyst fluids into the blood seemed to be an uncommon occurrence.
采用体外生物测定法，对14例小脑成血管细胞瘤患者的血清、囊液和肿瘤匀浆中的促红细胞生成活性进行了测定。只有2例患者外周血红细胞计数和血红蛋白浓度升高。仅1例患者血清促红细胞生成活性显著升高。然而，在14份囊液中的7份以及2份检测的匀浆中检测到高水平。这些样本的剂量反应曲线与正常人促红细胞生成素的曲线平行。用抗人促红细胞生成素血清可中和囊液中的促红细胞生成活性，表明其与正常促红细胞生成调节激素促红细胞生成素相似。囊液中的促红细胞生成刺激因子向血液中的显著释放似乎并不常见。
