Ismail S M, Jasani B, Cole G
J Clin Pathol. 1985 Apr;38(4):417-21. doi: 10.1136/jcp.38.4.417.
The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.
运用免疫细胞化学和电子显微镜技术,对1例von Hippel-Lindau综合征患者的小脑、视网膜及其中1个脊髓血管母细胞瘤进行了研究。肿瘤神经元特异性烯醇化酶呈阳性,生长抑素、胰多肽和蛙皮素呈不同程度阳性。小脑肿瘤的电子显微镜检查显示,分泌颗粒的平均直径为170 nm。据信,本报告首次描述了血管母细胞瘤血管周细胞内神经元特异性烯醇化酶阳性及多肽激素情况。基于这些发现,提示血管母细胞瘤是神经外胚层起源的肿瘤,来源于神经细胞或神经内分泌细胞。