Trout D L, Ryan R O, Bickard M C, Brendza D J
J Nutr. 1982 Jun;112(6):1151-61. doi: 10.1093/jn/112.6.1151.
Male rats (designated "meal-feeders") were trained for at least 21 days to eat voraciously for 2 hour a day a high-glucose, nutritionally adequate diet, while "nibblers" were fed the same diet ad libitum. In experiment 1, a second control group received the same amount of diet as eaten by meal-feeders but in four meals per day. Final test meals comprised either 10g per (kilogram body weight)3/4 or all that the animal would eat in a 2-hour period. With both sizes of test meal, gastric emptying of fat and/or glucose was greater in meal-feeders than in either control groups. In experiment 2, gastric emptying of glucose and fat was measured in meal-feeders and nibblers during three intervals of the dark period and during the 12-hour light period. An unusually rapid gastric emptying of glucose and of metabolic energy was observed in meal-feeders but was confined to the early period after the start of the daily meal. Glucose was emptied preferentially to fat under all test conditions. This tendency was prominent, however, only when a small meal was fed or after stomach contents had declined.
雄性大鼠（称为“大量进食者”）接受至少21天的训练，每天狼吞虎咽地吃两小时高糖且营养充足的食物，而“少量进食者”则随意进食相同的食物。在实验1中，第二个对照组摄入的食物量与大量进食者相同，但分为每天四餐。最终测试餐包括每（千克体重）3/4为10克或动物在两小时内会吃掉的全部食物量。无论测试餐的量大小，大量进食者脂肪和/或葡萄糖的胃排空速度都比两个对照组更快。在实验2中，测量了大量进食者和少量进食者在黑暗期的三个时间段以及12小时光照期内葡萄糖和脂肪的胃排空情况。在大量进食者中观察到葡萄糖和代谢能量的胃排空异常迅速，但仅限于每日进食开始后的早期阶段。在所有测试条件下，葡萄糖的排空都优先于脂肪。然而，只有在喂食少量食物或胃内容物减少后，这种趋势才会明显。
