Dyer R S, Walsh T J, Wonderlin W F, Bercegeay M
Neurobehav Toxicol Teratol. 1982 Mar-Apr;4(2):127-33.
Trimethyltin (TMT) chloride, administered to adult male Long-Evans hooded rats, produced a unique and distinctive behavioral syndrome consisting of spontaneous seizures, tail mutilation, vocalization and hyperreactivity. The LD50 for TMT was weight dependent; in large rats (e.g., 450 g), 7 mg/kg TMT produced significant weight loss and lethality, whereas in small rats (e.g., 250 g), 7 mg/kg produced neither weight loss nor lethality. TMT produced mild hypothermia and tremors. Results are discussed in comparison with kainic acid-induced morphological alterations and septal lesion-induced behavioral alterations. Histopathological evaluations of hippocampal tissue revealed cell loss that was largely confined to regio inferior pyramidal cells. TMT offers potential as a tool for investigations of limbic system structure and function.
给成年雄性长-伊文斯有帽大鼠注射氯化三甲基锡（TMT）后，会产生一种独特且与众不同的行为综合征，包括自发性癫痫发作、咬尾、发声和反应过度。TMT的半数致死剂量（LD50）取决于体重；在大型大鼠（如450克）中，7毫克/千克的TMT会导致显著体重减轻和死亡，而在小型大鼠（如250克）中，7毫克/千克既不会导致体重减轻也不会导致死亡。TMT会引起轻度体温过低和震颤。将结果与 kainic 酸诱导的形态学改变和隔区损伤诱导的行为改变进行了比较讨论。海马组织的组织病理学评估显示细胞丢失，主要局限于下锥体区域的细胞。TMT作为研究边缘系统结构和功能的工具具有潜力。
