Hornbein T F, Eger E I, Winter P M, Smith G, Wetstone D, Smith K H
Anesth Analg. 1982 Jul;61(7):553-6.
The potency and anesthetic state produced by nitrous oxide alone were investigated in order to clarify its contribution to the effect of other anesthetic agents. Seven volunteers anesthetized with 1.55 atm absolute N2O in a pressure chamber displayed muscle rigidity with jerking movements, labored and rapid breathing, sweating, and dilated pupils. At 1.1 atm absolute N2O, relaxation and quiescence occurred, sweating ceased, and pupil size decreased. Determination of MAC (using tetanic electrical impulses as the noxious stimulus) produced a mean value of 1.04 +/- 0.10 (SE) atm absolute. All subjects complained of nausea and vomiting after anesthesia.
为了阐明一氧化二氮对其他麻醉剂效果的影响，研究了单独使用一氧化二氮产生的效能和麻醉状态。七名志愿者在压力舱中用1.55个绝对大气压的N2O麻醉，表现出肌肉僵硬并伴有抽搐动作、呼吸费力且急促、出汗以及瞳孔散大。在1.1个绝对大气压的N2O时，出现了放松和平静，出汗停止，瞳孔大小减小。MAC的测定（使用强直电脉冲作为有害刺激）得出平均值为1.04±0.10（标准误）个绝对大气压。所有受试者在麻醉后均抱怨有恶心和呕吐症状。
