Aggression and open-field activity of lead-exposed mice.

Blood lead levels were increased 11 to 18 times in mice that ingested a 5 mg/ml solution of lead acetate for 2 or 4 weeks, with no effect on weight gain. Although the lead treatment produced neither mortality nor obvious abnormalities, it nevertheless inhibited the development of isolation-induced aggression which was characteristic on the basis of changes in motor activity.