Drago F, Bohus B, Van Ree J M, Scapagnini U, De Wied D
Eur J Pharmacol. 1982 Apr 23;79(3-4):323-7. doi: 10.1016/0014-2999(82)90641-0.
Rats with long-term endogenous hyperprolactinaemia induced by pituitary homografts under the kidney capsule displayed an enhancement of amphetamine- and apomorphine-induced stereotypy, a facilitated acquisition of active avoidance behavior and a decreased responsiveness to electrical footshock. However, no difference between homografted and sham-operated rats was observed with respect to grooming behavior. It is concluded that at least two processes occur during prolonged hyperprolactinaemia, i.e. development of tolerance to prolactin with respect to enhanced grooming activity and of supersensitivity of postsynaptic dopaminergic receptor systems. These two processes may be dependent or independent from each other.
通过将垂体匀浆移植到肾被膜下诱导产生长期内源性高催乳素血症的大鼠，表现出对苯丙胺和阿扑吗啡诱导的刻板行为增强、主动回避行为习得加快以及对电休克的反应性降低。然而，在梳理行为方面，未观察到移植组大鼠和假手术组大鼠之间存在差异。得出的结论是，在长期高催乳素血症期间至少发生两个过程，即就增强的梳理活动而言对催乳素产生耐受性以及突触后多巴胺能受体系统超敏。这两个过程可能相互依赖或相互独立。
