Zintz K, Frank W
Vet Parasitol. 1982 Mar;10(1):47-56. doi: 10.1016/0304-4017(82)90006-1.
The effects of the anthelmintics febantel and mebendazole on Heterakis spumosa were investigated by means of transmission and scanning electron microscopy. Ultramorphological changes were only seen in the intestinal cells. Microtubules disappeared and granules were absent from the terminal web 12 h after treatment with either febantel or mebendazole, and up to 72 h after treatment, the number and size of autophagic vacuoles increased. Moreover the parasites became sluggish and were frequently rolled up like spiral springs. Destruction to microtubules and neurotoxic influences are discussed as possible modes of action.
通过透射电子显微镜和扫描电子显微镜研究了驱虫药非班太尔和甲苯咪唑对火鸡异刺线虫的作用。超微形态学变化仅在肠道细胞中可见。用非班太尔或甲苯咪唑处理12小时后，微管消失，终末网中颗粒缺失，处理后长达72小时，自噬泡的数量和大小增加。此外，寄生虫变得行动迟缓，经常像螺旋弹簧一样卷曲起来。讨论了微管破坏和神经毒性影响作为可能的作用方式。
