Kawahara M, Kitahata L M, Collins J G, Homma E
Anesth Analg. 1982 Sep;61(9):763-6.
The effects of sodium thiopental on the single-unit activity of cells in the nucleus reticularis gigantocellularis (NRGG) were examined in decerebrated cats. Only cells in the NRGC that responded exclusively to electrical stimulation of A-delta fibers (noxious stimulation) in the superficial radial nerve were studied. Sodium thiopental caused a significant, dose-dependent suppression of spontaneous and evoked neuronal activity of cells in the NRGC. Spontaneous activity was suppressed by 66% and 98% after intravenous administration of sodium thiopental, 2.5 mg/kg and 5.0 mg/kg, respectively. Evoked activity was suppressed by 65% and 79%. These findings, when added to previous reports of the suppressive effects of nitrous oxide, morphine sulfate, ketamine hydrochloride, and halothane, suggest the involvement of the NRGC in nociception and provide evidence that sodium thiopental significantly modifies the neuronal message about a noxious stimulus as recorded at the level of the NRGC.
在去大脑的猫身上研究了硫喷妥钠对巨细胞网状核（NRGG）中细胞单单位活动的影响。仅研究了NRGC中那些仅对桡神经浅支A-δ纤维电刺激（有害刺激）有反应的细胞。硫喷妥钠对NRGC中细胞的自发和诱发神经元活动产生了显著的、剂量依赖性的抑制作用。静脉注射2.5mg/kg和5.0mg/kg硫喷妥钠后，自发活动分别被抑制了66%和98%。诱发活动被抑制了65%和79%。这些发现，再加上之前关于氧化亚氮、硫酸吗啡、盐酸氯胺酮和氟烷抑制作用的报道，提示NRGC参与伤害感受，并提供了证据表明硫喷妥钠显著改变了在NRGC水平记录到的关于有害刺激的神经元信息。
