[溴必利：犬体内的代谢与尿排泄（作者译）]
[Bromopride: metabolism and urinary elimination in dogs (author's transl)].
作者信息
Imbs J, Leibenguth A, Koffel J C, Jung L
出版信息
Arzneimittelforschung. 1982;32(5):503-8.
PMID:7201827
Abstract
The elimination of bromopride and its metabolites was studied in dogs. The drug was given by mouth in a single dose of 15 mg/kg or 45 mg/kg and assessed by thin-layer or gas chromatography. Bromopride and its metabolites are excreted mainly within the first 8 h after ingestion. Nine metabolites, above all the N-monodeethyl derivative, were encountered, while 10% of the drug was eliminated as such.
摘要
在犬类动物中研究了溴必利及其代谢物的消除情况。以15mg/kg或45mg/kg的单次口服剂量给药，并用薄层色谱法或气相色谱法进行评估。溴必利及其代谢物主要在摄入后的前8小时内排出。共发现了9种代谢物，其中主要是N-单去乙基衍生物，同时有10%的药物原样排出。
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