吲哚拉明抑制中枢交感反应性。

Central sympathetic reactivity inhibited by indoramin.

作者信息

Davison M, Koss M

出版信息

Eur J Pharmacol. 1980 Nov 21;68(2):193-6. doi: 10.1016/0014-2999(80)90321-0.

PMID:7202486

Abstract

The action of indoramin on central autonomic activity was investigated using the sympathetic-cholinergic electrodermal response system. Indoramin (0.33-10 mg/kg, i.v.) significantly reduced the amplitude of electrodermal responses (EDR) evoked by stimulation of the hypothalamus in a dose-related manner. The CNS effects of indoramin on the EDR were partially antagonized by yohombine pretreatment. These results demonstrate that indoramin reduces central sympathetic reactivity and suggest that an alpha-adrenergic inhibitory mechanism may be involved.

摘要

使用交感胆碱能皮肤电反应系统研究了吲哚拉明对中枢自主神经活动的作用。静脉注射吲哚拉明（0.33 - 10毫克/千克）以剂量相关的方式显著降低了下丘脑刺激诱发的皮肤电反应（EDR）幅度。育亨宾预处理可部分拮抗吲哚拉明对EDR的中枢神经系统作用。这些结果表明吲哚拉明降低了中枢交感反应性，并提示可能涉及α-肾上腺素能抑制机制。