Schuil H A, Brunsting J R, van der Molen H, Zijlstra W G
Eur J Pharmacol. 1981 Jan 16;69(2):229-33. doi: 10.1016/0014-2999(81)90421-0.
To test whether the tachycardia in response to atropine after adrenergic blockade is partly due to a central excitatory action, the effects of atropine, methylatropine and methylscopolamine were compared in dogs in neurolept-anesthesia. The latter two agents proved to have effect, similar to atropine. A central action is therefore improbable. It was possible to partly abolish the tachycardia by hexamethonium. The cardioacceleration by atropine, methylatropine and methylscopolamine, so far as it is not caused by muscarinic receptor blockade, can be explained by the unmasking of an underlying acceleratory tone.
为了检验肾上腺素能阻断后对阿托品产生的心动过速是否部分归因于中枢兴奋作用，在神经安定麻醉的犬中比较了阿托品、甲基阿托品和甲基东莨菪碱的作用。结果证明后两种药物与阿托品有相似作用。因此，不太可能存在中枢作用。六甲铵可部分消除心动过速。阿托品、甲基阿托品和甲基东莨菪碱引起的心动加速，只要不是由毒蕈碱受体阻断所致，就可以用解除潜在的加速性紧张来解释。
