Hayasaka I, Nakatsuka T, Fujii T, Naruse I, Oda S
Jikken Dobutsu. 1980 Oct;29(4):391-5. doi: 10.1538/expanim1978.29.4_391.
A new hereditary polydactyly (gene symbol Pdn) was found in the course of breeding JCL : ICR mice. The genetic analysis indicated that the polydactyly was an autosomal dominant trait. The homozygotes died within two days after birth. The homozygous fetuses or newborn had 1-3 extra-digits both in te fore- and hindlimbs on the preaxial side. They occasionally showed exencephaly, cleft palate, open eyelid, short tibia and fibula or deformed sternum. The heterozygotes had one extra-digit preaxial side. They occasionally showed exencephaly, heterozygotes had one extra-digit preaxially in the hindlimb and an enlarged first digit on the forelimb which often showed bifurcated distal phalanx. A tab on the postaxial side of the forelimb was found in all homozygotes and in some heterozygotes.
在培育JCL:ICR小鼠的过程中发现了一种新的遗传性多指（基因符号Pdn）。遗传分析表明，多指是一种常染色体显性性状。纯合子在出生后两天内死亡。纯合胎儿或新生儿在前肢和后肢的轴前侧均有1至3个额外的指（趾）。它们偶尔会出现无脑畸形、腭裂、眼睑未闭、胫腓骨短小或胸骨畸形。杂合子在轴前侧有一个额外的指（趾）。它们偶尔会出现无脑畸形，杂合子在后肢轴前侧有一个额外的指（趾），前肢的第一指增大，其远端指骨常呈分叉状。在所有纯合子和一些杂合子的前肢轴后侧发现一个小突出。
