Ishihara C
Jikken Dobutsu. 1980 Oct;29(4):427-32. doi: 10.1538/expanim1978.29.4_427.
A skin disease showing marked erythema and subsequent epidermal exfoliation has recently been observed in our breeding colony of guinea pigs. The distribution of staphylococcal antibodies and the frequency of Staphylococcus aureus isolation were studied in 5 guinea pig groups, three of which were in the clinical stages of the exfoliative skin disease, and two control groups. The mean titers of anti-alpha-toxin antibodies exhibited peak levels in the group of the middle clinical stage (titer of 24.0), when compared to those in the groups of the early (titer of 3.5) or the late clinical stages (titer of 4.1). The percentage of positive sera (titers greater than or equal to 5) for this antibody was also greater in the group of the middle clinical stage (100%) than in the groups of the early (55%) or the late clinical stages (64%). The agglutinating antibody was detected only in the groups of the early and the middle clinical stages. Staphylococcus aureus was isolated from 73% of the animals in the early stage, and from only 11% of those in the late stage.
最近在我们的豚鼠繁殖群体中观察到一种表现为明显红斑和随后表皮脱落的皮肤病。对5组豚鼠进行了葡萄球菌抗体分布和金黄色葡萄球菌分离频率的研究，其中3组处于剥脱性皮肤病的临床阶段，另外2组为对照组。与早期临床阶段组（滴度为3.5）或晚期临床阶段组（滴度为4.1）相比，抗α毒素抗体的平均滴度在临床中期组呈现峰值水平（滴度为24.0）。该抗体阳性血清（滴度大于或等于5）的百分比在临床中期组（100%）也高于早期组（55%）或晚期组（64%）。仅在早期和中期临床阶段组中检测到凝集抗体。金黄色葡萄球菌在早期阶段的动物中分离率为73%，而在晚期阶段仅为11%。
