梗死心肌的体外制备。
In vitro preparation of infarcted myocardium.
作者信息
Sasyniuk B I
出版信息
Environ Health Perspect. 1978 Oct;26:233-42. doi: 10.1289/ehp.7826233.
Abstract
An isolated ventricular endocardial preparation removed from canine hearts one to two days after coronary artery occlusion and superfused in vitro is described. The alteration in electrophysiological characteristics of subendocardial Purkinje fibers surviving in infarcted regions and the relationship of these changes to the generation of ventricular arrhythmias is discussed. The advantages of such preparations for assessing the mechanism of action of antiarrhythmic drugs in post-infarction ventricular arrhythmias is discussed.
摘要
本文描述了一种从冠状动脉闭塞后1至2天的犬心脏中取出并在体外进行灌流的离体心室心内膜制剂。讨论了梗死区域内存活的心内膜下浦肯野纤维电生理特性的改变，以及这些变化与室性心律失常发生的关系。还讨论了这种制剂在评估抗心律失常药物对心肌梗死后室性心律失常作用机制方面的优势。
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