Abe Y, Irikura T
Nihon Yakurigaku Zasshi. 1980 Sep;76(5):355-61.
In dogs and rabbits anesthetized with pentobarbital sodium or urethane, respectively, the gastric mucosal blood flow was measured by the thermoelectrical method after intravenous administration of 3-(3, 4, 5-trimethoxybenzamido)piperidine(KU-54), an antiulcer drug. In the gastric corpus of rabbits, the maximal mucosal blood flow (11.9%) was attained within 1 min after KU-54(5 mg/kg i.v.) dosing and there was a prolonged increase during 8 min. Administration of KU-54 produced a transitory depression of the blood pressure by about 20%, and induced a beta-adrenergic-like action, presumably because both the blood pressure depression and the gastric mucosal blood flow increment were simultaneous in rabbits. This phenomenon was however, not abolished by pretreatment with propranolol, a beta-adrenergic blocker, therefore KU-54 may not be a beta-adrenergic blocking agent. Administration of gefarnate, a standard antiulcer drug, produced a slight increase in gastric mucosal blood flow and response to this drug was less than that seen with KU-54. Sulpiride, a standard antiulcer drug, two peaks on the gastric mucosal blood flow increment in rabbits and the pattern of blood flow increment differed from that seen with KU-54. The increment of gastric mucosal blood flow produced by KU-54 (5 mg/kg i.v.) was more successive in the gastric antrum than that in the gastric corpus. In fasting rabbits, the main period of gastric mucosal blood flow increment produced by KU-54 (5 mg/kg i.v.) was more successive than that seen in the non-fasting animals. In dogs, the maximal blood flow (16%) was observed at 7 min after KU-54 (5 mg/KG i.v.) dosing and there was a prolonged increase during 6 min.
分别用戊巴比妥钠或氨基甲酸乙酯麻醉的犬和兔，静脉注射抗溃疡药物3-(3,4,5-三甲氧基苯甲酰胺基)哌啶（KU-54）后，采用热电法测量胃黏膜血流量。在兔的胃体部，静脉注射5mg/kg KU-54后1分钟内胃黏膜血流量达到最大值（11.9%），并在8分钟内持续增加。注射KU-54会使血压暂时下降约20%，并诱发类似β-肾上腺素能的作用，推测是因为在兔身上血压下降和胃黏膜血流量增加同时出现。然而，预先用β-肾上腺素能阻滞剂普萘洛尔处理并不能消除这种现象，因此KU-54可能不是β-肾上腺素能阻滞剂。标准抗溃疡药物吉法酯给药后胃黏膜血流量略有增加，对该药物的反应小于KU-54。标准抗溃疡药物舒必利使兔胃黏膜血流量增加出现两个峰值，血流量增加模式与KU-54不同。静脉注射5mg/kg KU-54引起的胃窦部胃黏膜血流量增加比胃体部更连续。在禁食的兔中，静脉注射5mg/kg KU-54引起的胃黏膜血流量增加的主要时间段比非禁食动物更连续。在犬中，静脉注射5mg/KG KU-54后7分钟观察到最大血流量（16%），并在6分钟内持续增加。
