Haughton V M, Davis J P, Harris G J, Ho K C
Invest Radiol. 1980 Jul-Aug;15(4):343-5. doi: 10.1097/00004424-198007000-00012.
The safety of metrizamide in the optic nerve sheath has not been studied to our knowledge. We studied histologic changes produced by metrizamide in the optic nerve of cats with surgically created lesions simulating orbital tumors and trauma. Displacement, compression, and disruption of the optic nerve sheath were detectable by radiographing the opacified sheath. Arachnoiditis of the optic nerve sheath is unlikely from a single exposure to metrizamide in a concentration less than 300mg I/ml.
据我们所知，尚未对甲泛葡胺在视神经鞘中的安全性进行研究。我们研究了甲泛葡胺对猫视神经产生的组织学变化，这些猫通过手术制造了模拟眼眶肿瘤和创伤的病变。通过对视神经鞘造影，可以检测到视神经鞘的移位、受压和破坏。单次暴露于浓度低于300mg I/ml的甲泛葡胺不太可能引起视神经鞘蛛网膜炎。
