Rosenberg F J, Romano J J, Shaw D D
Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S275-9.
Experiments were conducted on anesthetized rabbits to determine the effect of internal carotid artery injection of various contrast media on permeability changes in the blood-brain barrier. Changes in respiratory pattern, neuromuscular effects, and trypan blue extravasation were recorded after 3-ml injections of ionic and nonionic contrast media. Metrizamide and iothalamate meglumine were compared at iodine doses of 300, 400, and 500 mg I/ml. Metrizoate at 280 and 440 mg I/ml and diatrizoate meglumine at 385 mg I/ml were also included for comparison. The results demonstrated that metrizamide at all three iodine concentrations used caused minimal disruption of the blood-brain barrier, the effect being no greater, statistically, than saline controls. Iothalamate was benign at the lowest iodine concentration, but caused significant barrier breakdown at the two higher concentrations. These results suggest that alterations in blood-brain barrier permeability following angiography are mediated by both hyperosmolality of the contrast medium and the chemotoxicity of the contrast molecule.
在麻醉兔身上进行实验，以确定颈内动脉注射各种造影剂对血脑屏障通透性变化的影响。在注射3毫升离子型和非离子型造影剂后，记录呼吸模式变化、神经肌肉效应和锥虫蓝外渗情况。在碘剂量为300、400和500毫克碘/毫升的情况下，对甲泛葡胺和碘他拉葡胺进行了比较。还纳入了280和440毫克碘/毫升的泛影葡胺以及385毫克碘/毫升的泛影葡胺钠进行比较。结果表明，在所使用的所有三种碘浓度下，甲泛葡胺对血脑屏障的破坏最小，从统计学角度来看，其效果并不比生理盐水对照组更明显。碘他拉葡胺在最低碘浓度时是良性的，但在两个较高浓度时会导致血脑屏障明显破坏。这些结果表明，血管造影术后血脑屏障通透性的改变是由造影剂的高渗性和造影剂分子的化学毒性共同介导的。
