Chabloz R, Givel J C, Saraga P, Saegesser F
Helv Chir Acta. 1980 Dec;47(5):547-53.
We report 30 cases of non-Hodgkin's gastric lymphomas (according to the Rappaport classification): 1 nodular lymphocytic lymphoma well differentiated, 7 diffuse lymphocytic lymphomas poorly differentiated, 2 diffuse mixed cellularity lymphomas, 20 diffuse histiocytic lymphomas and 4 pseudolymphomas, over a period of 21 years at the CHUV, in Lausanne (1958-1979). There are 56% of advanced stages (IIIE and IVE) according to Ann Arbor. Survival to 5 years is of 27%. The mean survival of patients who died from their lymphomas is of 5 months only. Lymph node invasion worsens considerably the prognosis (75% of survival to 5 years for stage IE against 25% for stage IIE). This phenomenon is particular to non-ganglionary lymphomas. We do not observe good remission for the diffuse histiocytic forms at an advanced stage, remission being characteristic of the ganglionary lymphomas only. Treatment is poorly codified. Surgery along seems possible for the localised forms (IE): triple therapy (surgery, radiotherapy and chemotherapy) is necessary for advanced stages and histological unfavorable forms.
我们报告了洛桑大学中心医院(CHUV,1958 - 1979年)21年间收治的30例非霍奇金胃淋巴瘤(根据Rappaport分类):1例高分化结节性淋巴细胞淋巴瘤、7例低分化弥漫性淋巴细胞淋巴瘤、2例弥漫性混合细胞淋巴瘤、20例弥漫性组织细胞淋巴瘤和4例假淋巴瘤。根据Ann Arbor分期,晚期(IIIE和IVE期)占56%。5年生存率为27%。死于淋巴瘤的患者平均生存期仅5个月。淋巴结受累显著恶化预后(IE期5年生存率75%,而IIE期为25%)。这种现象在非结外淋巴瘤中尤为突出。我们未观察到晚期弥漫性组织细胞型有良好缓解,缓解仅为结内淋巴瘤的特征。治疗方案尚无统一规范。局限性病变(IE期)似乎仅手术即可;晚期及组织学表现不佳的类型则需要三联治疗(手术、放疗和化疗)。