Barie P S, Hakim T S, Malik A B
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):102-6. doi: 10.1152/jappl.1981.50.1.102.
We determined the effect of pulmonary hypoperfusion on extravascular water accumulation in anesthetized dogs by occluding the left pulmonary artery for 3 h and then reperfusing it for 24 h. The lung was reperfused either at normal left atrial pressure (Pla) or during increased Pla induced by a left atrial balloon. In each case the extravascular water content-to-bloodless dry weight ratio (W/D) of the left lung was compared with that of the right lung. The W/D of the left lung of 3.26 +/- 0.49 ml/g was not significantly different from the value of 2.87 +/- 0.37 for the right lung after the reperfusion at normal Pla. However, the W/D of the left lung of 5.10 +/- 0.38 ml/g was greater (P less than 0.05) than the value of 4.42 +/- 0.34 for the right lung after reperfusion at Pla of 25 Torr. This difference could not be prevented by pretreatment with heparin, suggesting that the increase in lung water content was not due to activation of intravascular coagulation secondary to stasis occurring during the occlusion. Because the left lung was more edematous than the right one, even though both lungs had been subjected to the same increase in Pla, the results suggest that a period of pulmonary hypoperfusion causes an increase in the interstitial protein concentration.
我们通过阻断麻醉犬的左肺动脉3小时，然后再灌注24小时，来确定肺灌注不足对血管外水分积聚的影响。肺在正常左心房压力（Pla）下或在左心房球囊诱导的Pla升高期间进行再灌注。在每种情况下，将左肺的血管外水含量与无血干重之比（W/D）与右肺的该比值进行比较。在正常Pla下再灌注后，左肺的W/D为3.26±0.49 ml/g，与右肺的2.87±0.37的值无显著差异。然而，在25 Torr的Pla下再灌注后，左肺的W/D为5.10±0.38 ml/g，大于右肺的4.42±0.34的值（P<0.05）。肝素预处理无法预防这种差异，这表明肺含水量的增加不是由于阻断期间发生的淤滞继发的血管内凝血激活所致。因为即使两肺的Pla升高相同，但左肺比右肺更水肿，结果表明一段时间的肺灌注不足会导致间质蛋白浓度升高。
