Thrall D E, Goldschmidt M H, Biery D N
J Am Vet Med Assoc. 1981 Jan 15;178(2):127-32.
The radiation response of acanthomatous epulis in 32 dogs was good, with an estimated median survival time of 21 months. Of the 32 patients, 14 have died. In 4 of those 14, malignant tumors developed at the site of the acanthomatous epulis. The tumors were of epithelial origin in 3 patients and of mesenchymal origin in 1 patient. Possibilities explaining the appearance of the malignancies included spontaneous malignant transformation, radiation induction of neoplasms, and radiation induction of malignant transformation. This uncommon complication was not considered contradictory to radiotherapy of acanthomatous epulides, because of their excellent response to irradiation and the long latent period between irradiation and appearance of the malignant tumor.
32只犬的棘皮瘤型龈瘤对放疗反应良好，估计中位生存时间为21个月。32例病犬中，14只已经死亡。在这14只死亡病犬中，有4只在棘皮瘤型龈瘤部位发生了恶性肿瘤。其中3例肿瘤起源于上皮组织，1例起源于间叶组织。恶性肿瘤出现的可能原因包括自发恶性转化、放疗诱发肿瘤以及放疗诱发恶性转化。这种罕见的并发症并不被认为与棘皮瘤型龈瘤的放射治疗相矛盾，因为它们对放疗反应良好，且放疗与恶性肿瘤出现之间的潜伏期较长。
